Setting description

several treatments more effective in distinctive signatures: (Hormone_therapies, TP53- & AR-); (Taxel_therapies, TEfus); (Carboplatin, DRD+)

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
—+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
-+– param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+–+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
++– param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
DRD+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 25, median = 18 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 2.85, hr = 0.33 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 8 5 0 2
TP53- & AR- 323 2 1 2
TP53+ 1 25 7 5
DRD+ 0 0 164 172
TEfus+ 1 197 3 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.016 0.010 0.000 0.004
TP53- & AR- 0.646 0.004 0.002 0.004
TP53+ 0.002 0.050 0.014 0.010
DRD+ 0.000 0.000 0.328 0.344
TEfus+ 0.002 0.394 0.006 0.004
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 1 0 0 0
TP53- & AR- 3 86 43 51
TP53+ 275 0 0 0
DRD+ 33 5 0 0
TEfus+ 103 0 5 5
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.002 0.000 0.000 0.000
TP53- & AR- 0.006 0.172 0.086 0.102
TP53+ 0.550 0.000 0.000 0.000
DRD+ 0.066 0.010 0.000 0.000
TEfus+ 0.206 0.000 0.010 0.010
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 106 8 35 32
TP53+ 2 29 16 13
DRD+ 0 0 0 0
TEfus+ 0 33 1 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.212 0.016 0.070 0.064
TP53+ 0.004 0.058 0.032 0.026
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.066 0.002 0.000


Errors & power

The overall error was 0.064.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.010             0.030             0.012             0.014

The overall power was 0.894.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.646             0.394             0.328             0.344

Median results at the end of the trial

By signature:
signature var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
all graduation 0 0 8 2 5
futility 0 0 1 0 0
max_n 0 0 0 0 0
n 176 (116, 257) 462 (431, 493) 144 (85, 244) 181 (121, 254) 188 (103, 254)
n_unique 161 (105, 241) 423 (398, 451) 134 (78, 230) 165 (110, 238) 174 (92, 237)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) NA (NA, NA) 4 (4, 7) 6 (5, 6) 5 (4, 7)
post_p 0.92 (0.25, 1) NA (NA, NA) 0.89 (0.19, 1) 0.86 (0.16, 1) 0.99 (0.48, 1)
rate 0.08 (0.064, 0.099) 0.094 (0.087, 0.102) 0.079 (0.062, 0.101) 0.081 (0.064, 0.103) 0.071 (0.057, 0.091)
DRD+ graduation 164 0 0 172 0
futility 0 0 33 0 5
max_n 0 0 0 0 0
n 79 (30, 107) 117 (100, 137) 24 (14, 39) 75 (31, 105) 35 (19, 57)
n_unique 73 (28, 99) 105 (89, 123) 22 (12, 36) 69 (28, 94) 31 (17, 51)
time_trial 36 (13, 36) 36 (36, 36) 36 (36, 36) 36 (14, 36) 36 (36, 36)
time_stop 18 (11, 34) NA (NA, NA) 28 (22, 35) 20 (11, 32) 28 (22, 34)
post_p 1 (1, 1) NA (NA, NA) 0.2 (0.02, 0.78) 1 (1, 1) 0.81 (0.24, 0.99)
rate 0.036 (0.028, 0.044) 0.092 (0.078, 0.106) 0.107 (0.072, 0.175) 0.036 (0.029, 0.044) 0.068 (0.048, 0.1)
TEfus+ graduation 3 0 1 2 197
futility 5 0 103 5 0
max_n 1 0 0 0 33
n 63 (40, 98) 170 (149, 189) 35 (23, 58) 62 (38, 98) 112 (30, 144)
n_unique 57 (35, 89) 153 (135, 172) 32 (20, 54) 56 (34, 89) 102 (28, 133)
time_trial 36 (36, 36) 36 (36, 36) 36 (24, 36) 36 (36, 36) 36 (11, 36)
time_stop 16 (12, 20) NA (NA, NA) 25 (16, 34) 18 (10, 33) 14 (9, 30)
post_p 0.7 (0.11, 0.98) NA (NA, NA) 0.07 (0, 0.46) 0.7 (0.13, 0.98) 1 (0.99, 1)
rate 0.067 (0.049, 0.094) 0.075 (0.065, 0.086) 0.103 (0.076, 0.143) 0.066 (0.05, 0.089) 0.038 (0.031, 0.045)
TP53- & AR- graduation 1 0 323 2 2
futility 43 0 3 51 86
max_n 35 0 106 32 8
n 54 (27, 137) 198 (179, 217) 48 (26, 152) 55 (27, 140) 41 (24, 100)
n_unique 49 (24, 132) 183 (164, 202) 46 (25, 146) 48 (25, 131) 36 (20, 95)
time_trial 36 (36, 36) 36 (36, 36) 12 (7, 36) 36 (34, 36) 36 (23, 36)
time_stop 18 (12, 29) NA (NA, NA) 9 (6, 18) 19 (13, 32) 20 (12, 32)
post_p 0.45 (0, 0.96) NA (NA, NA) 1 (0.95, 1) 0.41 (0, 0.96) 0.4 (0.01, 0.93)
rate 0.076 (0.05, 0.117) 0.075 (0.067, 0.085) 0.043 (0.033, 0.052) 0.079 (0.051, 0.119) 0.08 (0.053, 0.121)
TP53+ graduation 7 0 1 5 25
futility 0 0 275 0 0
max_n 16 0 2 13 29
n 82 (50, 121) 200 (180, 222) 51 (27, 94) 84 (52, 123) 108 (47, 144)
n_unique 75 (45, 113) 183 (163, 203) 47 (25, 87) 77 (46, 115) 100 (44, 133)
time_trial 36 (36, 36) 36 (36, 36) 32 (13, 36) 36 (36, 36) 36 (36, 36)
time_stop 10 (8, 14) NA (NA, NA) 20 (12, 32) 15 (10, 17) 10 (7, 18)
post_p 0.95 (0.46, 1) NA (NA, NA) 0.02 (0, 0.15) 0.92 (0.46, 1) 1 (0.85, 1)
rate 0.085 (0.063, 0.111) 0.113 (0.1, 0.126) 0.163 (0.137, 0.208) 0.088 (0.064, 0.112) 0.067 (0.05, 0.09)


By subgroup combinations:
subtype var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
—- graduation 44 0 332 55 93
futility 0 0 0 0 0
max_n 35 0 106 32 8
n 17 (7, 97) 132 (115, 148) 39 (21, 126) 16 (6, 100) 14 (7, 78)
n_unique 14 (5, 92) 122 (107, 139) 37 (20, 121) 14 (5, 96) 12 (6, 75)
post_p 0.03 (0, 0.14) NA (NA, NA) 1 (0.99, 1) 0.03 (0, 0.16) 0.04 (0, 0.18)
rate 0.168 (0.129, 0.294) 0.084 (0.072, 0.097) 0.043 (0.033, 0.053) 0.168 (0.134, 0.296) 0.173 (0.131, 0.277)
—+ graduation 50 0 369 61 271
futility 0 0 0 0 0
max_n 36 0 103 32 39
n 5 (2, 18) 23 (17, 31) 5 (2, 17) 5 (2, 16) 13 (3, 25)
n_unique 4 (2, 16) 21 (15, 28) 5 (2, 16) 4 (2, 14) 12 (3, 23)
post_p 0.13 (0.01, 0.31) NA (NA, NA) 0.69 (0.32, 0.92) 0.13 (0.03, 0.28) 0.8 (0.42, 0.97)
rate 0.179 (0.107, 0.445) 0.051 (0.035, 0.075) 0.045 (0.021, 0.101) 0.183 (0.107, 0.476) 0.039 (0.022, 0.071)
–+- graduation 7 0 285 7 29
futility 0 0 0 0 0
max_n 16 0 2 13 29
n 21 (5, 56) 66 (53, 79) 19 (8, 53) 26 (6, 56) 24 (6, 58)
n_unique 19 (5, 53) 61 (47, 73) 18 (7, 51) 24 (6, 52) 21 (5, 55)
post_p 0.29 (0.08, 0.75) NA (NA, NA) 0.33 (0.09, 0.76) 0.34 (0.1, 0.73) 0.34 (0.08, 0.79)
rate 0.173 (0.132, 0.335) 0.146 (0.122, 0.173) 0.17 (0.131, 0.277) 0.17 (0.131, 0.297) 0.168 (0.126, 0.31)
–++ graduation 14 0 327 14 210
futility 0 0 0 0 0
max_n 17 0 2 13 60
n 8 (3, 32) 49 (40, 60) 6 (3, 15) 8 (3, 30) 40 (11, 55)
n_unique 7 (3, 30) 45 (37, 56) 5 (2, 14) 7 (3, 28) 37 (10, 52)
post_p 0.15 (0.03, 0.36) NA (NA, NA) 0.16 (0.06, 0.36) 0.15 (0.03, 0.38) 1 (0.94, 1)
rate 0.172 (0.113, 0.391) 0.086 (0.067, 0.11) 0.182 (0.119, 0.393) 0.171 (0.112, 0.376) 0.038 (0.027, 0.051)
-+– graduation 198 0 341 221 97
futility 0 0 0 0 0
max_n 32 0 104 31 8
n 14 (4, 24) 21 (15, 29) 3 (0, 10) 13 (4, 23) 4 (2, 10)
n_unique 13 (4, 22) 19 (13, 27) 2 (0, 10) 12 (4, 21) 3 (1, 9)
post_p 0.91 (0.52, 0.99) NA (NA, NA) 0.68 (0.34, 0.92) 0.89 (0.49, 0.99) 0.2 (0.07, 0.4)
rate 0.035 (0.02, 0.069) 0.085 (0.059, 0.127) 0.047 (0.015, 0.134) 0.038 (0.02, 0.074) 0.181 (0.096, 0.584)
-+-+ graduation 203 0 373 224 274
futility 0 0 0 0 0
max_n 33 0 101 31 39
n 11 (4, 24) 21 (14, 29) 3 (0, 10) 12 (4, 23) 6 (1, 16)
n_unique 10 (3, 22) 19 (12, 26) 2 (0, 9) 10 (4, 22) 5 (1, 14)
post_p 0.66 (0.27, 0.91) NA (NA, NA) 0.51 (0.27, 0.81) 0.68 (0.3, 0.92) 0.58 (0.27, 0.85)
rate 0.036 (0.02, 0.072) 0.053 (0.035, 0.077) 0.049 (0.017, 0.132) 0.035 (0.02, 0.071) 0.04 (0.018, 0.101)
-++- graduation 166 0 298 176 33
futility 0 0 0 0 0
max_n 12 0 2 13 29
n 8 (2, 15) 12 (7, 18) 2 (1, 6) 8 (2, 15) 3 (1, 7)
n_unique 7 (2, 14) 11 (7, 16) 2 (0, 6) 7 (2, 14) 2 (1, 6)
post_p 0.93 (0.65, 1) NA (NA, NA) 0.35 (0.2, 0.59) 0.91 (0.56, 1) 0.34 (0.17, 0.58)
rate 0.037 (0.014, 0.085) 0.15 (0.099, 0.226) 0.184 (0.088, 0.696) 0.037 (0.014, 0.097) 0.179 (0.083, 0.635)
-+++ graduation 173 0 334 180 213
futility 0 0 0 0 0
max_n 13 0 2 13 60
n 7 (2, 15) 12 (8, 18) 2 (1, 5) 7 (2, 13) 3 (0, 10)
n_unique 7 (2, 13) 11 (7, 16) 2 (0, 4) 6 (2, 12) 3 (0, 9)
post_p 0.78 (0.44, 0.96) NA (NA, NA) 0.29 (0.13, 0.42) 0.77 (0.44, 0.96) 0.67 (0.36, 0.93)
rate 0.037 (0.017, 0.085) 0.085 (0.052, 0.14) 0.2 (0.093, 0.679) 0.038 (0.016, 0.086) 0.041 (0, 0.152)
+— graduation 0 0 9 2 5
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 7 (2, 18) 21 (15, 28) 8 (3, 20) 7 (2, 17) 11 (3, 21)
n_unique 7 (2, 17) 19 (13, 25) 7 (2, 18) 7 (2, 16) 9 (3, 19)
post_p 0.41 (0.17, 0.81) NA (NA, NA) 0.4 (0.16, 0.78) 0.43 (0.19, 0.82) 0.42 (0.15, 0.82)
rate 0.178 (0.108, 0.529) 0.148 (0.109, 0.206) 0.183 (0.112, 0.457) 0.174 (0.106, 0.511) 0.171 (0.113, 0.404)
+–+ graduation 8 0 113 9 201
futility 0 0 0 0 0
max_n 1 0 0 0 33
n 4 (2, 11) 18 (12, 25) 4 (2, 11) 4 (2, 12) 13 (3, 23)
n_unique 4 (1, 10) 16 (11, 23) 4 (1, 9) 4 (1, 11) 12 (3, 21)
post_p 0.25 (0.11, 0.49) NA (NA, NA) 0.26 (0.12, 0.51) 0.25 (0.11, 0.48) 0.95 (0.66, 1)
rate 0.202 (0.102, 0.605) 0.086 (0.056, 0.128) 0.183 (0.098, 0.47) 0.19 (0.1, 0.528) 0.038 (0.02, 0.071)
+-+- graduation 7 0 285 7 29
futility 0 0 0 0 0
max_n 16 0 2 13 29
n 6 (2, 16) 16 (11, 23) 5 (1, 14) 6 (2, 16) 7 (3, 18)
n_unique 6 (2, 15) 15 (10, 22) 4 (1, 13) 6 (2, 14) 6 (2, 16)
post_p 0.41 (0.19, 0.81) NA (NA, NA) 0.39 (0.2, 0.79) 0.37 (0.18, 0.77) 0.42 (0.17, 0.8)
rate 0.179 (0.106, 0.511) 0.146 (0.105, 0.21) 0.192 (0.11, 0.583) 0.195 (0.115, 0.464) 0.176 (0.114, 0.421)
+-++ graduation 14 0 327 14 210
futility 0 0 0 0 0
max_n 17 0 2 13 60
n 4 (2, 12) 18 (13, 25) 4 (1, 10) 5 (2, 13) 12 (3, 22)
n_unique 4 (1, 11) 16 (11, 22) 3 (1, 9) 4 (2, 12) 11 (3, 20)
post_p 0.25 (0.1, 0.47) NA (NA, NA) 0.28 (0.12, 0.51) 0.25 (0.1, 0.48) 0.95 (0.68, 1)
rate 0.189 (0.106, 0.472) 0.087 (0.056, 0.134) 0.183 (0.106, 0.516) 0.181 (0.105, 0.453) 0.039 (0.023, 0.07)
++– graduation 164 0 42 174 10
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (2, 15) 12 (8, 17) 3 (1, 6) 8 (2, 15) 3 (1, 7)
n_unique 7 (2, 14) 11 (7, 16) 3 (1, 6) 7 (2, 14) 3 (1, 6)
post_p 0.94 (0.6, 1) NA (NA, NA) 0.34 (0.18, 0.56) 0.93 (0.61, 1) 0.33 (0.18, 0.59)
rate 0.037 (0.016, 0.085) 0.148 (0.1, 0.242) 0.193 (0.094, 0.576) 0.038 (0.015, 0.092) 0.192 (0.094, 0.719)
++-+ graduation 171 0 132 178 205
futility 0 0 0 0 0
max_n 1 0 0 0 33
n 7 (2, 15) 12 (8, 18) 3 (1, 6) 7 (2, 13) 4 (1, 11)
n_unique 7 (2, 14) 11 (7, 16) 2 (1, 5) 6 (2, 12) 3 (1, 10)
post_p 0.77 (0.44, 0.96) NA (NA, NA) 0.25 (0.12, 0.44) 0.77 (0.37, 0.96) 0.7 (0.38, 0.93)
rate 0.038 (0.017, 0.088) 0.086 (0.051, 0.144) 0.185 (0.096, 0.59) 0.037 (0.016, 0.117) 0.04 (0.011, 0.109)
+++- graduation 166 0 298 176 33
futility 0 0 0 0 0
max_n 12 0 2 13 29
n 8 (2, 16) 12 (7, 18) 2 (1, 6) 8 (2, 14) 3 (1, 7)
n_unique 7 (2, 14) 11 (6, 16) 2 (0, 5) 7 (2, 13) 3 (1, 7)
post_p 0.93 (0.59, 1) NA (NA, NA) 0.34 (0.2, 0.56) 0.92 (0.59, 1) 0.34 (0.17, 0.59)
rate 0.037 (0.015, 0.089) 0.149 (0.102, 0.233) 0.206 (0.097, 0.747) 0.037 (0.015, 0.087) 0.186 (0.091, 0.588)
++++ graduation 173 0 334 180 213
futility 0 0 0 0 0
max_n 13 0 2 13 60
n 7 (2, 15) 12 (8, 18) 2 (1, 5) 7 (2, 14) 4 (0, 11)
n_unique 6 (2, 13) 11 (7, 16) 2 (0, 5) 6 (2, 13) 3 (0, 10)
post_p 0.76 (0.41, 0.96) NA (NA, NA) 0.27 (0.13, 0.41) 0.77 (0.47, 0.96) 0.69 (0.36, 0.92)
rate 0.038 (0.018, 0.091) 0.089 (0.054, 0.144) 0.215 (0.101, 0.71) 0.038 (0.014, 0.085) 0.042 (0.011, 0.145)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Niraparib Carboplatin
all count 8 5 2
time_stop 4 (4, 7) 5 (4, 7) 6 (5, 6)
n_trt 30 (25, 50) 27 (26, 41) 33 (27, 39)
n_control 52 (46, 72) 60 (45, 83) 65 (63, 67)
post_p 0.93 (0.87, 0.97) 0.89 (0.87, 0.96) 0.94 (0.91, 0.98)
order 1 (1, 1.3) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 323 2 2 1
time_stop 9 (6, 19) 13 (13, 13) 12 (10, 13) 20 (20, 20)
n_trt 34 (26, 75) 31 (27, 35) 26 (25, 26) 45 (45, 45)
n_control 42 (28, 94) 54 (51, 57) 55 (53, 57) 96 (96, 96)
post_p 0.94 (0.87, 1) 0.95 (0.92, 0.98) 0.97 (0.95, 0.98) 0.95 (0.95, 0.95)
order 1 (1, 2) 2 (2, 2) 2.5 (2.1, 2.9) 3 (3, 3)
TP53+ count 1 25 5 7
time_stop 7 (7, 7) 10 (7, 18) 15 (10, 17) 10 (8, 14)
n_trt 26 (26, 26) 37 (29, 55) 34 (30, 46) 27 (26, 40)
n_control 33 (33, 33) 53 (31, 93) 76 (49, 96) 51 (41, 73)
post_p 0.88 (0.88, 0.88) 0.98 (0.92, 1) 1 (0.96, 1) 0.98 (0.95, 0.99)
order 1 (1, 1) 2 (1, 2) 2 (1, 2) 1 (1, 2.4)
DRD+ count 172 164
time_stop 20 (11, 32) 18 (11, 34)
n_trt 42 (26, 84) 39 (26, 88)
n_control 56 (29, 115) 50 (28, 105)
post_p 1 (0.97, 1) 1 (0.98, 1)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 1 197 2 3
time_stop 16 (16, 16) 14 (9, 30) 10 (10, 10) 12 (11, 13)
n_trt 25 (25, 25) 40 (27, 104) 28 (26, 30) 25 (25, 26)
n_control 62 (62, 62) 55 (33, 138) 49 (42, 56) 49 (41, 60)
post_p 0.87 (0.87, 0.87) 0.99 (0.93, 1) 0.98 (0.97, 0.98) 0.96 (0.94, 0.97)
order 3 (3, 3) 2 (1, 3) 2 (2, 2) 2 (1.2, 2)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 1
time_stop 4 (4, 4)
n_trt 26 (26, 26)
n_control 52 (52, 52)
post_p 0.06 (0.06, 0.06)
order 1 (1, 1)
TP53- & AR- count 3 86 43 51
time_stop 9 (8, 9) 21 (12, 32) 17 (12, 30) 19 (13, 32)
n_trt 31 (28, 34) 30 (25, 58) 28 (25, 61) 32 (25, 65)
n_control 37 (31, 37) 106 (52, 174) 90 (57, 155) 96 (56, 180)
post_p 0.27 (0.26, 0.28) 0.11 (0.01, 0.26) 0.1 (0.01, 0.26) 0.09 (0.01, 0.24)
order 1 (1, 1) 1 (1, 2) 1 (1, 2.8) 1 (1, 3)
TP53+ count 275
time_stop 20 (12, 32)
n_trt 36 (26, 67)
n_control 101 (54, 169)
post_p 0.02 (0, 0.1)
order 1 (1, 2)
DRD+ count 33 5
time_stop 28 (22, 35) 28 (22, 34)
n_trt 26 (25, 31) 27 (25, 36)
n_control 81 (56, 113) 92 (64, 113)
post_p 0.05 (0.01, 0.18) 0.08 (0.03, 0.16)
order 2 (1, 3) 2 (1.4, 2.6)
TEfus+ count 103 5 5
time_stop 25 (16, 34) 19 (15, 21) 29 (14, 34)
n_trt 30 (25, 53) 27 (26, 48) 31 (25, 63)
n_control 108 (61, 156) 72 (60, 83) 137 (60, 154)
post_p 0.02 (0, 0.11) 0.08 (0.01, 0.26) 0.03 (0.01, 0.14)
order 2 (1, 3) 2 (1, 2.6) 3 (1.4, 3.6)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
time 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7)
n 16 (10, 22) 2 (1, 5) 8 (4, 12) 1 (0, 4) 0 (0, 1) 0 (0, 3) 0 (0, 0) 0 (0, 1) 1 (0, 2) 2 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1)
post_p 0.85 (0.75, 0.92) 0.58 (0.53, 0.66) 0.72 (0.63, 0.79) 0.53 (0.51, 0.57) 0.56 (0.52, 0.61) 0.54 (0.52, 0.55) 0.6 (0.6, 0.6) 0.55 (0.55, 0.55) 0.59 (0.53, 0.63) 0.6 (0.51, 0.68) 0.67 (0.63, 0.71) 0.53 (0.52, 0.54) NA (NA, NA) 0.5 (0.5, 0.5) 0.63 (0.54, 0.72) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.022 (0, 0.044) 0 (0, 0.59) 0.094 (0.025, 0.13) 0 (0, 0.055) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.084) 0 (0, 0.102) 0 (0, 0.061) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0.485) 0.175 (0.175, 0.175)
Niraparib count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6)
n 1 (0, 2) 2 (1, 4) 4 (1, 6) 2 (0, 3) 4 (2, 6) 6 (5, 6) 4 (4, 4) 2 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 2 (2, 3) 2 (0, 3) 2 (0, 3) 4 (2, 5)
post_p 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.54 (0.54, 0.54) 0.52 (0.52, 0.52) 0.52 (0.52, 0.53) 0.55 (0.55, 0.56) 0.64 (0.59, 0.69) 0.54 (0.54, 0.54) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) 0.57 (0.57, 0.57) 0.62 (0.6, 0.63) 0.64 (0.64, 0.64) 0.59 (0.59, 0.59) 0.7 (0.56, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.054 (0.054, 0.054) 0 (0, 0) 0.031 (0.006, 0.055) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.085 (0.017, 0.154) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
time 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7)
n 5 (4, 8) 5 (1, 8) 3 (3, 6) 6 (5, 12) 0 (0, 0) 0 (0, 1) 0 (0, 2) 0 (0, 2) 1 (1, 3) 3 (0, 3) 1 (1, 4) 1 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0)
post_p 0.59 (0.52, 0.63) 0.58 (0.55, 0.79) 0.59 (0.52, 0.7) 0.68 (0.63, 0.77) NA (NA, NA) 0.53 (0.51, 0.54) 0.55 (0.54, 0.56) 0.59 (0.53, 0.65) 0.66 (0.52, 0.75) 0.6 (0.58, 0.69) 0.56 (0.53, 0.61) 0.67 (0.66, 0.72) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.056 (0.045, 0.071) 0 (0, 0.016) 0.129 (0.093, 0.164) 0 (0, 0.044) NA (NA, NA) 0 (0, 0) 0.181 (0.036, 0.325) 0 (0, 0) 0 (0, 0.178) 0 (0, 0.053) 0 (0, 0.261) 0 (0, 0.036) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
DRD+ Carboplatin count 164 164 164 164 164 164 164 164
time 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34)
n 8 (3, 19) 8 (3, 18) 5 (1, 11) 5 (1, 11) 5 (1, 12) 4 (1, 11) 4 (1, 12) 4 (1, 11)
post_p 0.8 (0.57, 0.96) 0.73 (0.54, 0.86) 0.76 (0.56, 0.94) 0.74 (0.54, 0.91) 0.82 (0.56, 0.97) 0.7 (0.53, 0.9) 0.78 (0.56, 0.96) 0.72 (0.53, 0.91)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.028 (0, 0.056) 0.023 (0, 0.043) 0.026 (0, 0.074) 0.023 (0, 0.062) 0.031 (0, 0.072) 0.025 (0, 0.066) 0.031 (0, 0.076) 0.025 (0, 0.059)
Niraparib count 172 172 172 172 172 172 172 172
time 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32)
n 8 (3, 17) 8 (3, 18) 5 (1, 10) 5 (1, 10) 4 (1, 10) 4 (2, 12) 4 (2, 10) 4 (1, 11)
post_p 0.79 (0.62, 0.94) 0.73 (0.55, 0.88) 0.79 (0.55, 0.96) 0.72 (0.53, 0.9) 0.78 (0.53, 0.97) 0.71 (0.53, 0.91) 0.77 (0.55, 0.95) 0.7 (0.55, 0.91)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.028 (0, 0.055) 0.022 (0, 0.042) 0.029 (0, 0.076) 0.025 (0, 0.059) 0.025 (0, 0.079) 0.025 (0, 0.069) 0.034 (0, 0.079) 0.026 (0, 0.063)
TEfus+ Carboplatin count 3 3 3 3 3 3 3 3
time 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13)
n 0 (0, 3) 4 (2, 6) 4 (3, 5) 3 (1, 6) 3 (2, 3) 1 (0, 4) 4 (2, 5) 3 (2, 6)
post_p 0.5 (0.5, 0.5) 0.62 (0.56, 0.82) 0.79 (0.64, 0.82) 0.58 (0.55, 0.69) 0.6 (0.52, 0.67) 0.56 (0.52, 0.6) 0.62 (0.58, 0.64) 0.62 (0.59, 0.81)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.032 (0.006, 0.056) 0 (0, 0.067) 0 (0, 0.076) 0.087 (0.017, 0.119) 0.03 (0.006, 0.055) 0 (0, 0.022) 0 (0, 0.012)
Hormone_therapies count 1 1 1 1 1 1 1 1
time 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16)
n 1 (1, 1) 10 (10, 10) 2 (2, 2) 1 (1, 1) 3 (3, 3) 6 (6, 6) 1 (1, 1) 1 (1, 1)
post_p 0.62 (0.62, 0.62) 0.75 (0.75, 0.75) 0.67 (0.67, 0.67) 0.62 (0.62, 0.62) 0.56 (0.56, 0.56) 0.78 (0.78, 0.78) NA (NA, NA) 0.6 (0.6, 0.6)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0.058 (0.058, 0.058) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.113 (0.113, 0.113) 0.298 (0.298, 0.298) 0 (0, 0)
Niraparib count 2 2 2 2 2 2 2 2
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 0 (0, 1) 6 (4, 8) 6 (5, 6) 6 (5, 8) 0 (0, 1) 2 (1, 2) 4 (3, 5) 3 (2, 4)
post_p 0.59 (0.59, 0.59) 0.79 (0.75, 0.83) 0.73 (0.71, 0.76) 0.72 (0.65, 0.79) 0.55 (0.55, 0.55) 0.55 (0.54, 0.56) 0.64 (0.6, 0.67) 0.6 (0.58, 0.63)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.016 (0.003, 0.029) 0 (0, 0) 0.017 (0.003, 0.031) 0 (0, 0) 0.072 (0.014, 0.129) 0.022 (0.004, 0.039) 0 (0, 0)
Taxel_therapies count 197 197 197 197 197 197 197 197
time 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30)
n 6 (2, 17) 17 (9, 39) 3 (1, 10) 2 (0, 6) 6 (2, 15) 5 (2, 14) 2 (0, 6) 2 (0, 6)
post_p 0.73 (0.55, 0.9) 0.93 (0.75, 1) 0.57 (0.51, 0.79) 0.63 (0.52, 0.87) 0.84 (0.61, 0.98) 0.79 (0.58, 0.98) 0.6 (0.51, 0.79) 0.6 (0.52, 0.82)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.025 (0, 0.049) 0.035 (0.014, 0.065) 0 (0, 0.041) 0 (0, 0.051) 0.029 (0, 0.058) 0.028 (0, 0.074) 0 (0, 0.06) 0 (0, 0.053)
TP53- & AR- Carboplatin count 1 1 1 1
time 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20)
n 28 (28, 28) 2 (2, 2) 4 (4, 4) 11 (11, 11)
post_p 0.76 (0.76, 0.76) 0.6 (0.6, 0.6) 0.74 (0.74, 0.74) 0.79 (0.79, 0.79)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.076 (0.076, 0.076) 0 (0, 0) 0.039 (0.039, 0.039) 0.014 (0.014, 0.014)
Hormone_therapies count 323 323 323 323
time 9 (6, 19) 9 (6, 19) 9 (6, 19) 9 (6, 19)
n 28 (21, 63) 4 (2, 9) 1 (0, 4) 1 (0, 5)
post_p 0.95 (0.84, 1) 0.65 (0.52, 0.81) 0.57 (0.51, 0.75) 0.56 (0.51, 0.71)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.036 (0.014, 0.056) 0 (0, 0.066) 0 (0, 0.06) 0 (0, 0.036)
Niraparib count 2 2 2 2
time 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13)
n 12 (12, 12) 0 (0, 0) 10 (8, 12) 4 (2, 6)
post_p 0.74 (0.72, 0.75) NA (NA, NA) 0.85 (0.79, 0.9) 0.63 (0.54, 0.73)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.039 (0.035, 0.043) NA (NA, NA) 0.011 (0.002, 0.02) 0 (0, 0)
Taxel_therapies count 2 2 2 2
time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
n 17 (15, 19) 8 (6, 9) 2 (1, 2) 5 (3, 7)
post_p 0.74 (0.71, 0.76) 0.93 (0.9, 0.96) 0.57 (0.55, 0.59) 0.71 (0.62, 0.8)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.084 (0.083, 0.086) 0.022 (0.021, 0.022) 0 (0, 0) 0 (0, 0)
TP53+ Carboplatin count 7 7 7 7 7 7 7 7
time 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14)
n 10 (5, 14) 4 (1, 9) 3 (2, 4) 2 (1, 3) 2 (0, 3) 3 (1, 5) 5 (3, 6) 2 (0, 5)
post_p 0.77 (0.67, 0.87) 0.61 (0.54, 0.79) 0.63 (0.54, 0.77) 0.56 (0.51, 0.68) 0.64 (0.57, 0.72) 0.55 (0.52, 0.66) 0.77 (0.74, 0.88) 0.71 (0.57, 0.88)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.1 (0.059, 0.142) 0.044 (0, 0.09) 0.042 (0, 0.091) 0 (0, 0.084) 0 (0, 0.046) 0.074 (0, 0.103) 0.024 (0, 0.054) 0 (0, 0.04)
Hormone_therapies count 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 14 (14, 14) 5 (5, 5) 1 (1, 1) 1 (1, 1) 4 (4, 4) 1 (1, 1) 0 (0, 0) 0 (0, 0)
post_p 0.79 (0.79, 0.79) 0.66 (0.66, 0.66) 0.56 (0.56, 0.56) 0.53 (0.53, 0.53) 0.65 (0.65, 0.65) 0.66 (0.66, 0.66) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.077 (0.077, 0.077) 0.082 (0.082, 0.082) 0 (0, 0) 0 (0, 0) 0.053 (0.053, 0.053) 0 (0, 0) NA (NA, NA) NA (NA, NA)
Niraparib count 5 5 5 5 5 5 5 5
time 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17)
n 9 (9, 20) 4 (1, 8) 6 (3, 7) 2 (1, 6) 3 (2, 5) 3 (2, 4) 3 (2, 4) 2 (1, 4)
post_p 0.74 (0.72, 0.84) 0.62 (0.55, 0.7) 0.78 (0.6, 1) 0.6 (0.57, 0.69) 0.6 (0.56, 0.8) 0.62 (0.56, 0.83) 0.7 (0.63, 0.79) 0.7 (0.62, 0.81)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.094 (0.072, 0.1) 0.076 (0.021, 0.086) 0 (0, 0.01) 0.038 (0, 0.082) 0.043 (0, 0.221) 0.027 (0, 0.094) 0 (0, 0.065) 0 (0, 0.02)
Taxel_therapies count 25 25 25 25 25 25 25 25
time 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18)
n 12 (5, 21) 14 (6, 22) 1 (0, 3) 1 (0, 4) 4 (2, 6) 4 (1, 10) 0 (0, 3) 1 (0, 3)
post_p 0.76 (0.7, 0.88) 0.84 (0.75, 0.97) 0.56 (0.52, 0.64) 0.61 (0.52, 0.67) 0.59 (0.52, 0.84) 0.7 (0.58, 0.95) 0.57 (0.52, 0.68) 0.58 (0.54, 0.71)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.1 (0.041, 0.141) 0.033 (0.007, 0.059) 0 (0, 0.149) 0 (0, 0.044) 0.102 (0.036, 0.196) 0 (0, 0.056) 0.062 (0, 0.131) 0 (0, 0.081)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 10 (10, 10) 2 (2, 2) 7 (7, 7) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 2 (2, 2) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.36 (0.36, 0.36) 0.48 (0.48, 0.48) 0.17 (0.17, 0.17) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.43 (0.43, 0.43) 0.37 (0.37, 0.37) NA (NA, NA) 0.35 (0.35, 0.35) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.129 (0.129, 0.129) 0 (0, 0) 0.293 (0.293, 0.293) 0.247 (0.247, 0.247) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.435 (0.435, 0.435) 0.127 (0.127, 0.127) NA (NA, NA) 5.011 (5.011, 5.011) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
DRD+ count 33 33 33 33 33 33 33 33
time 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35)
n 4 (0, 8) 4 (1, 9) 2 (0, 8) 3 (1, 5) 3 (2, 6) 4 (1, 6) 3 (1, 4) 3 (1, 5)
post_p 0.36 (0.29, 0.5) 0.41 (0.17, 0.48) 0.32 (0.2, 0.44) 0.29 (0.18, 0.4) 0.28 (0.18, 0.46) 0.25 (0.16, 0.39) 0.36 (0.19, 0.46) 0.24 (0.08, 0.38)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.094 (0.06, 0.158) 0.076 (0.039, 0.122) 0.181 (0.124, 0.626) 0.189 (0.117, 0.59) 0.237 (0.1, 0.514) 0.181 (0.107, 0.643) 0.209 (0.094, 0.445) 0.205 (0.108, 0.722)
Taxel_therapies count 5 5 5 5 5 5 5 5
time 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34)
n 5 (3, 11) 3 (1, 10) 4 (1, 7) 4 (1, 5) 2 (1, 4) 0 (0, 5) 2 (1, 4) 3 (2, 8)
post_p 0.22 (0.08, 0.3) 0.28 (0.18, 0.42) 0.29 (0.16, 0.41) 0.44 (0.36, 0.48) 0.2 (0.18, 0.27) 0.41 (0.35, 0.47) 0.31 (0.27, 0.42) 0.41 (0.29, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.18 (0.114, 0.297) 0.101 (0.063, 0.159) 0.229 (0.099, 0.732) 0.071 (0.055, 0.094) 0.325 (0.18, 1.032) 0.062 (0.042, 0.082) 0.151 (0.127, 0.47) 0.099 (0.05, 0.113)
TEfus+ Carboplatin count 5 5 5 5 5 5 5 5
time 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21)
n 2 (2, 6) 5 (3, 9) 6 (5, 9) 4 (0, 5) 2 (0, 6) 3 (3, 11) 4 (2, 8) 3 (2, 5)
post_p 0.39 (0.18, 0.47) 0.22 (0.09, 0.39) 0.37 (0.32, 0.39) 0.3 (0.18, 0.4) 0.27 (0.2, 0.44) 0.34 (0.23, 0.43) 0.46 (0.3, 0.5) 0.41 (0.23, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.11 (0.064, 0.46) 0.224 (0.153, 0.356) 0.047 (0.03, 0.055) 0.1 (0.073, 0.125) 0.196 (0.091, 0.473) 0.176 (0.152, 0.315) 0.076 (0.032, 0.229) 0.099 (0.068, 0.238)
Hormone_therapies count 103 103 103 103 103 103 103 103
time 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34)
n 5 (2, 15) 7 (3, 14) 3 (1, 10) 2 (0, 5) 4 (2, 8) 4 (1, 8) 2 (1, 5) 2 (1, 4)
post_p 0.41 (0.22, 0.49) 0.21 (0.08, 0.41) 0.39 (0.24, 0.48) 0.3 (0.14, 0.44) 0.29 (0.13, 0.46) 0.31 (0.13, 0.45) 0.28 (0.17, 0.42) 0.31 (0.16, 0.43)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.082 (0.053, 0.162) 0.173 (0.11, 0.407) 0.069 (0.039, 0.19) 0.193 (0.09, 0.622) 0.213 (0.097, 0.561) 0.187 (0.108, 0.545) 0.192 (0.088, 0.809) 0.199 (0.09, 0.79)
Niraparib count 5 5 5 5 5 5 5 5
time 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34)
n 6 (5, 20) 6 (3, 7) 4 (3, 17) 4 (3, 6) 3 (1, 3) 2 (1, 6) 2 (1, 5) 2 (1, 7)
post_p 0.13 (0.02, 0.23) 0.13 (0.07, 0.3) 0.47 (0.37, 0.49) 0.36 (0.29, 0.46) 0.27 (0.18, 0.44) 0.35 (0.25, 0.39) 0.3 (0.22, 0.47) 0.39 (0.29, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.154 (0.135, 0.188) 0.249 (0.155, 0.414) 0.06 (0.041, 0.069) 0.059 (0.048, 0.155) 0.304 (0.108, 0.478) 0.208 (0.147, 0.571) 0.158 (0.103, 0.542) 0.096 (0.078, 0.102)
TP53- & AR- Carboplatin count 43 43 43 43
time 17 (12, 30) 17 (12, 30) 17 (12, 30) 17 (12, 30)
n 18 (8, 40) 4 (1, 7) 5 (2, 10) 6 (2, 8)
post_p 0.18 (0.02, 0.39) 0.26 (0.1, 0.39) 0.42 (0.19, 0.49) 0.38 (0.22, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.156 (0.114, 0.204) 0.198 (0.07, 0.82) 0.087 (0.049, 0.345) 0.057 (0.037, 0.122)
Hormone_therapies count 3 3 3 3
time 9 (8, 9) 9 (8, 9) 9 (8, 9) 9 (8, 9)
n 24 (24, 26) 5 (3, 7) 0 (0, 0) 0 (0, 3)
post_p 0.4 (0.36, 0.47) 0.46 (0.44, 0.48) NA (NA, NA) 0.35 (0.35, 0.35)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.099 (0.092, 0.101) 0.063 (0.056, 0.073) NA (NA, NA) 0 (0, 0)
Niraparib count 51 51 51 51
time 19 (13, 32) 19 (13, 32) 19 (13, 32) 19 (13, 32)
n 17 (5, 39) 4 (1, 12) 6 (2, 12) 7 (3, 13)
post_p 0.1 (0.01, 0.28) 0.18 (0.06, 0.4) 0.36 (0.19, 0.49) 0.39 (0.22, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.179 (0.129, 0.341) 0.204 (0.093, 0.753) 0.09 (0.051, 0.23) 0.057 (0.037, 0.099)
Taxel_therapies count 86 86 86 86
time 21 (12, 32) 21 (12, 32) 21 (12, 32) 21 (12, 32)
n 15 (7, 36) 7 (3, 15) 4 (1, 7) 4 (0, 8)
post_p 0.13 (0.02, 0.38) 0.44 (0.28, 0.49) 0.29 (0.1, 0.4) 0.42 (0.18, 0.49)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.153 (0.107, 0.25) 0.069 (0.046, 0.132) 0.198 (0.08, 1.121) 0.066 (0.036, 0.209)
TP53+ Hormone_therapies count 275 275 275 275 275 275 275 275
time 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32)
n 15 (7, 35) 6 (3, 13) 2 (0, 5) 2 (0, 4) 3 (1, 8) 3 (1, 8) 2 (0, 4) 2 (0, 4)
post_p 0.33 (0.1, 0.46) 0.22 (0.07, 0.44) 0.34 (0.21, 0.47) 0.3 (0.16, 0.47) 0.37 (0.19, 0.48) 0.32 (0.16, 0.47) 0.34 (0.2, 0.47) 0.31 (0.15, 0.44)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.18 (0.14, 0.284) 0.177 (0.107, 0.399) 0.201 (0.1, 0.772) 0.202 (0.07, 0.793) 0.242 (0.143, 0.711) 0.184 (0.107, 0.611) 0.227 (0.104, 0.936) 0.222 (0.088, 0.93)